The Catholic diagnosis is broader than a single mechanism. Original sin names a wounded inherited condition; personal sin involves culpable choice; ignorance and passion can diminish freedom; social structures magnify evil; and Christ enters suffering to forgive, heal and raise the person.
The comparison begins from truths already established by reason: reality is intelligible, contradiction cannot be true in the same respect, moral obligation is not created by appetite, and contingent being requires a first principle. A religious claim may deepen these truths, but it cannot reverse them without forfeiting intelligibility.
The Church recognizes rays of truth, moral seriousness and providential preparation outside her visible bounds. Recognition is not relativism. Whatever is true has one divine source; whatever contradicts the revealed identity of God, the Incarnation or the saving work of Christ cannot be received as a parallel completion.
Christ is not placed at the end of a neutral catalogue as one option among many. His public life, death and resurrection are historical claims; his apostolic Church makes a visible claim of authority; and the credibility of these claims must be judged by evidence rather than by a prior rule that excludes unique revelation.
Sin, karma and ignorance name different diagnoses and cannot be merged into one religious psychology. The inquiry must ask whether evil is culpable privation, metaphysical illusion, ritual debt or ignorance, and whether the proposed remedy truly forgives, heals and restores the same responsible person.
The appropriate response to sin, karma, ignorance and suffering is neither contempt nor vague admiration. It is accurate quotation, patient distinction, positive proof of the Catholic position and an invitation to the fullness of truth and sacramental life in Christ.